Hi @R-S,

Thank you for sharing all this. I can see how carefully you’re tuning into your system right now, and that level of awareness really matters in this phase. After everything your body has been processing, the most supportive thing you can do is keep things simple and predictable.

Think of your system like a snow globe that was shaken a bit too much. Nothing inside is damaged, but the flakes are still swirling. You don’t clear that by adding more movement — you clear it by giving the globe enough rest so everything can settle again. That’s the phase you’re in.

Staying with zinc-carnosine once a day is a good idea right now. Increasing anything too quickly can feel like stimulation to a system that’s already alert. Once you have a few calm days in a row, you can check in with yourself and decide if you want to increase to twice a day.

For sequencing, the gentlest and clearest order is DAO first, then quercetin, then ProBiotaX. DAO is the easiest starting point because it doesn’t build up in your body (like Bernadette mentioned). it just helps break down histamine in the moment. Quercetin needs time to build, so introduce it after DAO feels stable. ProBiotaX should come last because probiotics can sometimes feel activating until the system adjusts. Give yourself three to five days between each introduction so your body has space to tell you clearly how it feels.

About the spacing with duloxetine: there’s no research showing that DAO interferes with duloxetine or affects how the medication works. DAO stays in the digestive tract and doesn’t impact the brain or the medication’s mechanism. The advice to separate them is mainly a precaution to keep duloxetine’s absorption steady and predictable. A simple spacing rule that works well for most people is to leave about two hours between DAO and your duloxetine. It’s not about danger… just about giving both their own space so your system stays calm.

Quercetin is best taken with food earlier in the day. ProBiotaX usually works well in the morning, unless that’s your most sensitive time, in which case lunch is also completely fine.

Pausing the enzymes was a wise move. When your system feels overstimulated, even helpful things can feel too loud. Once things feel steadier again, you can bring enzymes back once a day with your largest meal. This is important: Digestion doesn’t need to be perfect right now… it needs to feel safe.

The histamine overflow you’re experiencing is probably still linked to the emotional and physical load of the past weeks. Histamine rises whenever the body feels on guard. Your chemistry is just reflecting the state you were in. That’s why the most therapeutic thing right now is simplicity: one supplement at a time, gentle timing, and letting your nervous system lead the way.

And one last thought: sometimes gut symptoms spike because of stress around us, not just inside us. If there was anything or anyone stressful around the time things flared (and only if you feel comfortable!) you’re welcome to share that part too. Not to get emotional, but so we can look at the situation together and maybe give you some tools to handle those dynamics more safely.

Sometimes it’s the environment, not the body, that needs the adjustment.